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Abnormal subpopulations of monocytes in the cerebrospinal fluid of patients with Parkinson's disease

期刊

PARKINSONISM & RELATED DISORDERS
卷 84, 期 -, 页码 144-145

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ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2021.02.017

关键词

Subpopulations of monocytes; FACS; Cerebrospinal fluid; Peripheral blood; Pbmc; Innate immune system; Flow cytometry; Biomarker

资金

  1. EU/EFPIA Innovative Medicines Initiative Joint Undertaking (Aetionomy) [115568]

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Classical and nonclassical monocytes were found to be increased in the cerebrospinal fluid of Parkinson's Disease patients.
We performed immune cell profiling by multiparameter flow cytometry in cerebrospinal fluid (CSF) and peripheral blood (PB) of Parkinson's Disease (PD) patients (n = 9) and healthy controls (n = 8). Classical and nonclassical monocytes were increased in the CSF of PD patients.

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