期刊
PARKINSONISM & RELATED DISORDERS
卷 84, 期 -, 页码 23-28出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2021.01.019
关键词
Parkinson?s disease; Punding; Attention; Cognitive impairment
资金
- Michael J. Fox Foundation for Parkinson's Research
- Abbvie
- Allergan
- Amathus Therapeutics
- Avid Radiopharmaceuticals
- Biogen
- Biolegend
- Bristol-Myers Squibb
- Celgene
- Denali
- GE Healthcare
- Genentech
- GlaxoSmithKline
- Janssen Neuroscience
- Lilly
- Lundbeck
- Merck
- Meso Scale Discovery
- Pfizer
- Piramal
- Prevail Therapeutics
- Roche
- Sanofi Genzyme
- Servier
- Takeda
- Teva
- UCB
- Verily
- Voyager Therapeutics
- Golub Capital
The study found that in Parkinson's disease patients, Punding behavior was associated with attentional dysfunction, with lower scores on the primary attention test and attention subscale being linked to Punding behaviors. Additionally, functional impairment may be a predictive factor for Punding behavior, while hobbyism behavior is not associated with it.
Background: Punding is a complication of Parkinson's disease (PD) treatment and stimulant abuse that features excessive preoccupation with repetitive and/or aimless behaviors. We hypothesized that cognitive impairment and functional limitations influence how punding behaviors manifest in PD. Methods: We extracted data on punding, hobbyism, and cognition from the Parkinson's Progression Marker Initiative (PPMI). Punding and hobbyism were measured with the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease (QUIP) scale. We determined how cognition predicted punding and hobby ism behaviors-adjusting for levodopa dose, Hoehn & Yahr stage, disease duration, and age-using generalized estimating equation (GEE) logistic regression. Activities of daily living (ADL) and motor impairment were measured with the MDS-UPDRS scale. Results: In GEE logistic regression models, punding was selectively associated with lower scores on the Letter Number Sequencing test (LNS), the primary attention test in PPMI (Odds ratio: 0.87 (95% CI: 0.79-0.96); p = 0.022). This was corroborated by a subscale-analysis of Montreal Cognitive Assessment (MoCA) scores, as only the attention subscale was significantly associated with punding (OR: 0.59 (0.45-0.77); p < 0.001). Baseline impairment in LNS (Hazard ratio: 2.52 (1.22-5.20); p = 0.012) and MoCA attention (HR: 2.68 (1.32-5.42); p = 0.006) predicted earlier punding in Cox regression. In turn, ADL dysfunction predicted punding (OR: 1.55 (1.20-2.00); p < 0.001), but not hobbyism. Conclusion: Attentional dysfunction is a domain-specific cognitive biomarker of punding risk in PD. Further, attentional capacity and functional impairment may determine the complexity of perseverative behaviors on the continuum from rudimentary punding to semi-purposeful hobbyism.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据