期刊
PARASITES & VECTORS
卷 14, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13071-021-04655-z
关键词
Schistosomiasis; Diagnosis; Follow-up; Circulating anodic antigen (CAA); Serology; Microscopy; Migrants
资金
- Italian Ministry of Health Fondi Ricerca Corrente-L3P2
The study demonstrates that the UCP-LF CAA assay is beneficial for diagnosing schistosomiasis and is especially valuable for post-treatment monitoring, which is of significance for the migrant population.
Background: An accurate test for the diagnosis and post-treatment follow-up of patients with schistosomiasis is needed. We assessed the performance of different laboratory parameters, including the up-converting reporter particle technology lateral flow assay to detect circulating anodic antigen (UCP-LF CAA), for the post-treatment follow-up of schistosomiasis in migrants attending a dedicated outpatient clinic in a non-endemic country. Methods: Routine anti-Schistosoma serology results and eosinophil counts were obtained of patients with positive urine/stool microscopy and/or PCR (confirmed cases) or only positive serology (possible cases), and at least one follow-up visit at 6 (T6) or 12 (T12) months after praziquantel treatment. All sera samples were tested with the UCP-LF CAA assay. Results: Forty-eight patients were included, 23 confirmed and 25 possible cases. The percentage seropositivity and median antibody titers did not change significantly during follow-up. UCP-LF CAA was positive in 86.9% of confirmed and 20% of possible cases. The percentage positivity and median CAA levels decreased significantly post-treatment, with only two patients having positive CAA levels at T12. Conclusions: The UCP-LF CAA assay proved useful for the diagnosis of active infection with Schistosoma spp. and highly valuable for post-treatment monitoring in migrants, encouraging the development of a commercial test.
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