期刊
OSTEOARTHRITIS AND CARTILAGE
卷 29, 期 6, 页码 793-801出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.joca.2021.02.204
关键词
Intervertebral disc degeneration; NLRP3; Inflammasome; Intervertebral disc
资金
- Natural Science Foundation of China [31960175]
- Natural Science Foundation of Gansu Province [18JR3RA331]
- Cuiying Project of Lanzhou University Second Hospital [CY2017-MS06]
This article summarizes the role of the NLRP3 inflammasome in the pathogenesis of IVDD and its application in treatment.
Intervertebral disc degeneration (IVDD) is one of the leading causes of low back pain and one of the most common health problems in the world. The nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing-3 (NLRP3) inflammasome, as a pattern recognition receptor, has been shown to be associated with the pathological processes of many diseases in recent years. With the exploration of the mechanism of IVDD, recent studies have shown that activation of the NLRP3 inflammasome is associated with intervertebral disc (IVD) inflammation, pyroptosis, extracellular matrix degradation and apoptosis of IVD cells. In this review, we summarize the structural characteristics of NLRP3 inflammasome and the activation signalling mechanisms. We also describe the role of the NLRP3 inflammasome in the pathological process of IVDD and the application of the targeting the NLRP3 inflammasome in IVDD treatment. (c) 2021 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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