期刊
ORGANIC LETTERS
卷 23, 期 6, 页码 2199-2204出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c00345
关键词
-
资金
- National Natural Science Foundation of China [21732002, 22077071]
The study introduces an efficient and general method for synthesizing gamma-carbonyl alpha-amino acids through photoinduced decatungstate-catalyzed Giese reactions of readily available aldehydes as radical precursors. The mild and robust method is compatible with a wide array of functional groups and has a broad substrate scope. The utility of the method was demonstrated by modifying several amino acid bearing drugs and natural products.
Synthesis of unnatural amino acids has long been a focus of chemistry research. Here, we present an efficient, general method that furnishes gamma-carbonyl alpha-amino acids via photoinduced decatungstate-catalyzed Giese reactions of readily available aldehydes as radical precursors. This mild, robust method is compatible with a wide array of functional groups and has a broad substrate scope. We demonstrated the utility of the method by modifying several amino acid bearing drugs and natural products.
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