Diastereoselective Construction of Eight-Membered Carbocycles through Palladium-Catalyzed C(sp3)-H Functionalization

A palladium-catalyzed cross-coupling reaction of 2-alkylphenyl bromides with biphenylene has been developed. The reactions formed eight-membered carbocycles through C(sp(3))-H activation and the formation of two C-C bonds, and the chiral products were obtained with excellent diastereoselectivity. The reaction provides a new strategy for the construction of eight-membered carbocycles, and the products represent a novel type of chiral scaffold.

Automated summary

A palladium-catalyzed cross-coupling reaction has been developed for the synthesis of eight-membered carbocycles, featuring C(sp(3))-H activation and the formation of two C-C bonds with excellent diastereoselectivity. This reaction provides a new strategy for constructing eight-membered carbocycles and yields novel chiral scaffolds.