A Modular, Argon-Driven Flow Platform for Natural Product Synthesis and Late-Stage Transformations

A modular flow platform for natural product synthesis was designed. To access different reaction setups with a maximum of flexibility, interchangeable 3D-printed components serve as backbone. By switching from liquid- to gas-driven flow, reagent and solvent waste is minimized, which translates into an advantageous sustainability profile. To enable inert conditions, Schlenk-in-flow techniques for the safe handling of oxygen- and moisture sensitive reagents were developed. Adopting these techniques, reproducible transformations in natural product synthesis were achieved.

Automated summary

A modular flow platform was designed for natural product synthesis, utilizing interchangeable 3D-printed components for flexible reaction setups. By adopting liquid- to gas-driven flow, reagent and solvent waste is minimized, leading to a sustainable profile. Schlenk-in-flow techniques were developed for safe handling of sensitive reagents, enabling reproducible transformations in natural product synthesis.