期刊
ORGANIC LETTERS
卷 23, 期 6, 页码 2169-2173出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c00323
关键词
-
资金
- National Research Foundation of Korea (NRF) - Korean Government (Center for New Directions in Organic Synthesis) [NRF-2014-011165]
- NRF-2018 Fostering Core Leaders of the Future Basic Science Program/Global Ph.D. Fellowship Program - Korean Government
The total synthesis of (+/-)-hinckdentine A was achieved through a cyanide-catalyzed imino-Stetter reaction and oxidative rearrangement, followed by D-ring formation and seven-membered C-ring construction. The newly synthesized compound contains all functional groups correctly positioned in the natural product.
The total synthesis of (+/-)-hinckdentine A is described herein. A cyanide-catalyzed imino-Stetter reaction of the aldimine derived from ethyl 2-amino-3,5-dibromocinnamate and 5-bromo-2-nitrobenzaldehyde followed by oxidative rearrangement afforded a 2,2-disubstituted 3-indolinone derivative containing the carbon skeleton and all of the functional groups present in the natural product correctly positioned, including three bromine atoms. Subsequent D-ring formation and seven-membered C-ring construction completed the total synthesis of hinckdentine A.
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