期刊
ORGANIC LETTERS
卷 23, 期 6, 页码 2048-2051出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c00204
关键词
-
资金
- NSFC [21925109, 21772170]
- Outstanding Young Talents of Zhejiang Province Highlevel Personnel of Special Support [ZJWR0108]
The paper describes an asymmetric C-H activation strategy for accessing alpha,beta-stereospecific gamma-lactams in good yields with high enantio- and diastereoselectivities, serving as an effective supplement to existing strategies.
gamma-Lactam containing alpha,beta-contiguous stereogenic centers stands out as a pivotal motif in various bioactive compounds, while its efficient synthesis still needs to be enhanced. Herein, an asymmetric C-H activation strategy for accessing alpha,beta-stereospecific gamma-lactams in good yields (<= 79%) with high enantio- and diastereoselectivities (<= 96% ee and >20:1 dr) was described, which serves as an effective supplement to the existing strategies.
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