Dual-Wavelength Gated oxo-Diels-Alder Photoligation

The control of chemical functionalization with orthogonal light stimuli paves the way toward manipulating materials with unprecedented spatiotemporal resolution. To reach this goal, we herein introduce a photochemical reaction system that enables two-color control of covalent ligation via an oxo-Diels- Alder cycloaddition between two separate light-responsive molecular entities: a UV-activated photocaged diene based on ortho-quinodimethanes and a carbonyl dienophile appended to a diarylethene photoswitch, whose reactivity can be modulated upon illumination with UV and visible light.

Automated summary

By utilizing UV and visible light illumination, control of two-color light can be used to regulate covalent ligation, enabling precise manipulation within materials.