Organophotoredox-Catalyzed Three-Component Coupling of Heteroatom Nucleophiles, Alkenes, and Aliphatic Redox Active Esters

This manuscript describes a visible-light-mediated organo-photoredox catalytic process for vicinal difunctionalization of alkenes using heteroatom nucleophiles and aliphatic redox active esters. A wide range of heteroatom nucleophiles including alcohols, water, carboxylic acids, amides, and halogens can be used for this reaction. This radical relay type reaction allows forging of C(sp(3))-C(sp(3)) with a carbon centered radical and C(sp(3))-heteroatom bonds with a benzyl cation on the vinylarenes with complete regioselectivity in a single step.

Automated summary

This method describes a visible-light-mediated organo-photoredox catalytic process for vicinal difunctionalization of alkenes using heteroatom nucleophiles and aliphatic redox active esters. A wide range of heteroatom nucleophiles can be used for this reaction, allowing the forging of C(sp(3))-C(sp(3)) and C(sp(3))-heteroatom bonds with high regioselectivity in a single step.