Chiral C2-Symmetric Aminomethylbinaphthol as Synergistic Catalyst for Asymmetric Epoxidation of Alkylidenemalononitriles: Easy Access to Chiral Spirooxindoles

Chiral C-2-symmetric 3,3'-bis((R,R)-2-naphthylethylaminomethyl)-(R)-binaphthol (AMB4) functions as an efficient organocatalyst for the asymmetric epoxidation of various alkylidenemalononitriles. The spiro-epoxyoxindole products obtained from isatilidenemalononitriles were easily transformed to the corresponding chiral dihydroquinoxalinyl spirooxindoles.

Automated summary

AMB4 is an efficient organocatalyst for the asymmetric epoxidation of various alkylidenemalononitriles, leading to the formation of chiral dihydroquinoxalinyl spirooxindoles from isatilidenemalononitriles.