4.8 Article

Regio- and Trans-Selective Ni-Catalyzed Coupling of Butadiene, Carbonyls, and Arylboronic Acids to Homoallylic Alcohols under Base-Free Conditions

期刊

ORGANIC LETTERS
卷 23, 期 7, 页码 2571-2577

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c00488

关键词

-

资金

  1. National Natural Science Foundation of China [21690074, 21871288, 21821002, 91856111]
  2. Strategic Priority Research Program of the Chinese Academy of Sciences [XDB 20000000]

向作者/读者索取更多资源

This Ni-catalyzed three-component coupling reaction provides a general synthetic approach to 1,4-disubstituted homoallylic alcohols, which were previously difficult to access. The reaction is regioselective, trans-selective, and can tolerate highly base-sensitive functional groups under neutral conditions.
We herein report a Ni-catalyzed three-component coupling of 1,3-butadiene, carbonyl compounds, and arylboronic acids as a general synthetic approach to 1,4-disubstituted homoallylic alcohols, an important class of compounds, which have previously not been straightforward to access. The reaction occurs efficiently using a Ni(cod) 2 catalyst without any external base and ligand at ambient temperature and allows a highly regioselective and trans-selective 1,4-dicarbofunctionalization of feedstock butadiene in a single operation. This simple and practical protocol could apply to a comprehensive scope of substrates. The neutral conditions show extraordinary tolerance for even highly base-sensitive functional groups.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据