期刊
OPTICS LETTERS
卷 46, 期 7, 页码 1724-1727出版社
OPTICAL SOC AMER
DOI: 10.1364/OL.415368
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资金
- National Natural Science Foundation of China [61627827, 61705068, 81630046, 91539127]
- National High-tech Research and Development Program [2015AA020901]
- Science and Technology Planning Project of Guangdong Province [2014B020215003, 2015B020233016]
- Science and Technology Program of Guangzhou [2019050001]
The proposed method introduces a novel spectral interferometric depth-resolved photoacoustic viscoelasticity imaging technique, achieving internal visible microscale viscoelasticity imaging and demonstrating depth-resolved performance in one scan.
Viscoelasticity is closely related to the physiological characteristics of biological tissues. In this Letter, we propose a novel spectral interferometric depth-resolved photoacoustic viscoelasticity imaging (SID-PAVEI) method, to the best of our knowledge for the first time, which breaks the plight of surface viscoelasticity imaging and achieves an internal visible microscale SID-PAVEI in a noncontact fashion. In this work, we employ a high-sensitive and depth-resolved spectral domain low coherence interferometry (SDLCI) to remotely track photoacoustic-induced strain response of absorbers in situ. By decoupling the phase and amplitude of the photoacoustic-encoded spectral interference signal, the SID-PAVEI and scattering structure imaging (SSI) can be obtained simultaneously. Depth-resolved performance of the SID-PAVEI and the SSI in one scan were demonstrated by imaging biological tissues. The method opens new perspectives for three-dimensional microscale viscoelasticity imaging and provides a great potential in multi-parametric characterizing pathological information. (C) 2021 Optical Society of America.
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