期刊
OBESITY FACTS
卷 14, 期 1, 页码 93-99出版社
KARGER
DOI: 10.1159/000511918
关键词
LEP promoter methylation; LEPR promoter methylation; Leptin; Bariatric surgery; Obesity
资金
- Federal Ministry of Education and Research within the German Obesity Competence Network [01GI1323]
The study revealed significant differences in promoter methylation levels of LEP and LEPR genes between pre- and postbariatric surgery patients, with leptin serum levels showing a significant change before and after the surgery.
Introduction: DNA methylation constitutes one important epigenetic mechanism that regulates gene expression in human cells. With regard to obesity, bariatric surgery-induced weight loss has been associated with promoter methylation changes in several genes. Hyperleptinemia is a characteristic feature of obesity. The underlying regulating mechanisms have not yet been completely elucidated. Methods: We investigated the methylation of the promoters of the leptin gene (LEP) and the leptin receptor gene (LEPR) as well as leptin expression in pre- and postbariatric surgery patients using a comparative cross-sectional design. Results: Our results revealed significantly higher LEP promoter methylation patterns in prebariatric surgery patients compared to postoperatively. DNA methylation of the LEPR promoter was significantly higher in the postoperative group. Moreover, we found significantly higher leptin serum levels in patients before the bariatric surgery than afterwards. Discussion: These findings strengthen the suggestion that there is an association between LEP expression and LEP methylation in obesity. We suggest that the epigenetic profile of LEP might be influenced by leptin serum levels in the form of a regulating feedback mechanism.
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