期刊
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
卷 31, 期 3, 页码 782-792出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.numecd.2020.10.021
关键词
Chronic kidney disease; Body mass index; Waist circumference; Hip circumference; Waist-hip ratio
资金
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute - Ministry of Health & Welfare, Republic of Korea [HI16C1127]
This study investigated the association of baseline obesity measures and their trajectories over time with incident CKD. Results showed that baseline obesity in terms of BMI, WC, and HC increased the odds of CKD incidence, while baseline WHR did not show such an association. Nonobese BMI, WC, or WHR trajectories, and constantly not large HC trajectory decreased the hazard of CKD incidence compared to constantly obese or became obese trajectories.
Background and aims: We investigated the association of baseline obesity measures, i.e. body mass index (BMI), waist circumference (WC), hip circumference (HC), and waist-hip ratio (WHR), and their trajectories over time with incident chronic kidney disease (CKD). Methods and results: Utilizing data from 2001 to 2014 for 9796 Korean adults without CKD at baseline, the association of baseline obesity measures with incident CKD was evaluated using logistic regression. Further, among 5605 subjects with repeated measures, the effect of the trajectories in obesity measures on CKD incidence was investigated via Cox regression. Baseline obesity in terms of BMI, WC, and HC increased the odds of incident CKD (odds ratio (OR) 1.19, 95% confidence interval (CI) 1.05-1.33; OR 1.22, 95% CI 1.07-1.38; and OR 1.25, 95% CI 1.11-1.41, respectively), while baseline WHR did not show such an association. A became nonobese BMI, WC, or WHR trajectory, and a constantly not large HC trajectory decreased the hazard of incident CKD (hazard ratio (HR) 0.70, 95% CI 0.50-0.99; HR 0.61, 95% CI 0.40-0.92; HR 0.55, 95% CI 0.35-0.85; and HR 0.81, 95% CI 0.69-0.95, respectively) when compared with a constantly obese or became obese trajectory. Conclusion: Both baseline obesity and obesity trajectories over time were associated with CKD incidence. BMI and WC were equally good measures of CKD risk, while WHR was not. Separately examining WC and HC components of WHR ( = WC/HC) may explain WHR's inconsistency, and WHR's usefulness as a measure of CKD risk should be reevaluated. (C) 2020 Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据