期刊
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
卷 74, 期 2, 页码 622-639出版社
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/01635581.2021.1895234
关键词
-
资金
- Deanship of Scientific Research, King Khalid University, Abha, Saudia Arabia [R.G.P. 01/48/42]
The study found that glycyrrhizin (GLY) has anti-proliferative and apoptotic effects on HPV-C33A cervical cancer cells, inducing apoptosis and cell cycle arrest. This effect may be associated with GLY's impact on mitochondrial membrane potential and activation of multiple apoptotic signaling pathways.
Growing emphasis on exploring the antiproliferative potential of natural compounds has gathered momentum for the formulation of anticancer drugs. In the present study, the anticancer and apoptotic potential of glycyrrhizin (GLY) was studied on HPV- C33A cervical cancer (CCa) cells. Our results indicated that GLY exerted antiproliferative effects in the C33A cells by inducing significant cytotoxicity. Treatment with GLY substantially increases the apoptosis in a dose-dependent manner via disrupting the mitochondrial membrane potential. GLY induced apoptosis in C33A cells via activation of capsase-9 (intrinsic pathway) and caspase-8 (extrinsic pathway) along with the modulation of pro- and antiapoptotic protein expression. Moreover, GLY also exerted cell cycle arrest in C33A cells at G(0)/G(1) phase which was associated with the decreased expression of cyclin D1 and cyclin-dependent kinase 4 (CDK4) along with the increased expression of CDK inhibitor p21(Cip1). Furthermore, GLY treated CCa cells exhibited significant downregulation of Notch signaling pathway which may be associated with increased apoptosis as well as cell cycle arrest in C33A CCa cells. Thus, GLY could be an appendage in the prevention and management of CCa.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据