相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5′-(R)- and 5′-(S)-C-methyl-guanosine
Atsushi Mikami et al.
NUCLEIC ACIDS RESEARCH (2020)
Selective tissue targeting of synthetic nucleic acid drugs
Punit P. Seth et al.
JOURNAL OF CLINICAL INVESTIGATION (2019)
Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index
Wen Shen et al.
NATURE BIOTECHNOLOGY (2019)
Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins
Michael T. Migawa et al.
NUCLEIC ACIDS RESEARCH (2019)
Re-Engineering RNA Molecules into Therapeutic Agents
Martin Egli et al.
ACCOUNTS OF CHEMICAL RESEARCH (2019)
Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA
Mark K. Schlegel et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Cellular uptake and trafficking of antisense oligonucleotides
Stanley T. Crooke et al.
NATURE BIOTECHNOLOGY (2017)
Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides
Michael E. Ostergaard et al.
MOLECULAR THERAPY-NUCLEIC ACIDS (2017)
The Medicinal Chemistry of Therapeutic Oligonucleotides
W. Brad Wan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5′-C-Methyl Pyrimidine-Modified Oligonucleotides
Alexander V. Kel'in et al.
JOURNAL OF ORGANIC CHEMISTRY (2016)
Design, synthesis, and duplex-stabilizing properties of conformationally constrained tricyclic analogues of LNA
Robert D. Giacometti et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2016)
Identification of metabolically stable 5′- phosphate analogs that support single-stranded siRNA activity
Thazha P. Prakash et al.
NUCLEIC ACIDS RESEARCH (2015)
Differential Effects on Allele Selective Silencing of Mutant Huntingtin by Two Stereoisomers of α,β-Constrained Nucleic Acid
Michael E. Ostergaard et al.
ACS CHEMICAL BIOLOGY (2014)
Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS
Michael E. Ostergaard et al.
NUCLEIC ACIDS RESEARCH (2013)
Structure-Based Design of a Highly Constrained Nucleic Acid Analogue: Improved Duplex Stabilization by Restricting Sugar Pucker and Torsion Angle γ
Stephen Hanessian et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
Insights from Crystal Structures into the Opposite Effects on RNA Affinity Caused by the S- and R-6′-Methyl Backbone Modifications of 3′-Fluoro Hexitol Nucleic Acid
Pradeep S. Pallan et al.
BIOCHEMISTRY (2012)
Structural requirements for hybridization at the 5′-position are different in α-L-LNA as compared to β-D-LNA
Punit P. Seth et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
TricycloDNA-modified oligo-2′-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues-a comparative study of oligonucleotide length, design and chemistry
Sue Murray et al.
NUCLEIC ACIDS RESEARCH (2012)
Structure Activity Relationships of α-L-LNA Modified Phosphorothioate Gapmer Antisense Oligonucleotides in Animals
Punit P. Seth et al.
MOLECULAR THERAPY-NUCLEIC ACIDS (2012)
alpha,beta-D-CNA featuring canonical and noncanonical alpha/beta torsional angles behaviours within oligonucleotides
Arnaud Boissonnet et al.
NEW JOURNAL OF CHEMISTRY (2011)
Configuration of the 5′-Methyl Group Modulates the Biophysical and Biological Properties of Locked Nucleic Acid (LNA) Oligonucleotides
Punit P. Seth et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Mitsunobu and Related Reactions: Advances and Applications
K. C. Kumara Swamy et al.
CHEMICAL REVIEWS (2009)
Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles
Pradeep S. Pallan et al.
CHEMICAL COMMUNICATIONS (2008)
Structure of human RNase h1 complexed with an RNA/DNA hybrid: Insight into HIV reverse transcription
Marcin Nowotny et al.
MOLECULAR CELL (2007)
Watson-Crick base-pairing properties of nucleic acid analogues with stereocontrolled a and torsion angles (alpha,beta-D-CNAs)
Christelle Dupouy et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)
Ring-closing metathesis based synthesis of bicyclic nucleosides locked in S-type conformations by hydroxyl functionalised 3′,4′-trans linkages
M Freitag et al.
TETRAHEDRON (2004)
Dinucleotides of 4′-C-vinyl- and 5′-C-allylthymidine as substrates for ring-closing metathesis reactions
C Kirchhoff et al.
TETRAHEDRON LETTERS (2003)
Synthesis and NMR-studies of dinucleotides with conformationally restricted cyclic phosphotriester linkages
AM Sorensen et al.
TETRAHEDRON (2001)