期刊
NEUROSCIENCE LETTERS
卷 751, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2021.135811
关键词
Photothrombotic stroke; Cortical stroke; Photothrombosis; Hemisyndrome; Neuroscore; CatWalk XT; Behaviour; Gait analysis; Functional deficit assessment; Forelimb impairment; Coordinative dysfunction; Central pattern generators
资金
- Marga-and Walter-Boll Foundation
- Koeln Fortune program of the University of Cologne
- Deutsche Forschungsgemeinschaft [CRC1451]
The study evaluated CatWalk's capability for assessing functional outcomes after photothrombotic stroke in mice, finding that while CatWalk detected some impairments, a composite neuroscore may be more sensitive and precise in quantifying hemisyndromes induced by photothrombosis.
The purpose of this study was to evaluate CatWalk's capability for assessing the functional outcome after photothrombotic stroke affecting the motor cortex of mice. Mice were tested up to 21 days after photothrombosis or sham surgery using CatWalk, and a composite score assessing functional deficits (neuroscore). The neuroscore demonstrated deficits of the contralateral forelimb for more than two weeks after stroke. There were no asymmetric or coordinative dysfunctions of limbs detected by CatWalk. However, CatWalk data revealed impairment of locomotion speed and its depending parameters for one-week after stroke in strong correlation to the neuroscore. Data suggest that the composite neuroscore allows to more sensitively and precisely specify and quantify photothrombosis-induced hemisyndromes than CatWalk.
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