Microtubules, actin and cytolinkers: how to connect cytoskeletons in the neuronal growth cone

Cytolinkers ensure the integration of the different cytoskeleton components in the neuronal growth cone during development and in the course of axon regeneration. In neurons, an integrated skeleton guarantees appropriate function, and connectivity of high order circuits. Over the past years, several cytoskeleton regulatory proteins with actin-microtubule crosslinking activity have been identified. In neurons, the importance of spectrins, formins and other cytolinkers capable of coupling actin and microtubules has been extensively highlighted during axon outgrowth and guidance. In this Review, we discuss the current knowledge on cytolinkers specifically expressed in the neuronal growth cone of developing and regenerating axons.

Automated summary

Cytolinkers play a crucial role in ensuring the integration of different cytoskeleton components in neurons, which is essential for proper function and connectivity of high order circuits. Several cytoskeleton regulatory proteins with actin-microtubule crosslinking activity have been identified as important players in axon outgrowth and guidance.