期刊
NEUROPSYCHOLOGY REVIEW
卷 31, 期 4, 页码 703-720出版社
SPRINGER
DOI: 10.1007/s11065-021-09479-3
关键词
Gray matter atrophy; Multiple sclerosis; Cortico-striatal-thalamic networks; Sensorimotor network
资金
- National Natural Science Foundation of China [81771812, 81971595]
- Innovation Spark Project of Sichuan University [2019SCUH0003]
- 1.3.5 Project for Disciplines of Excellence-Clinical Research Incubation Project, West China Hospital, Sichuan University [2020HXFH005]
Gray matter atrophy is associated with disability and cognitive impairment in multiple sclerosis, and differences in atrophy patterns between relapsing-remitting and primary progressive MS were identified. Specific gray matter regions were associated with disease characteristics in RRMS and PPMS, suggesting common and distinct pathogenesis between the two types of MS.
Gray matter atrophy in multiple sclerosis (MS) is thought to be associated with disability and cognitive impairment, but previous studies have sometimes had discordant results, and the atrophy patterns of relapsing-remitting multiple sclerosis (RRMS) and primary progressive multiple sclerosis (PPMS) remain to be clarified. We conducted a meta-analysis using anisotropic effect-size-based algorithms (AES-SDM) to identify consistent findings from whole-brain voxel-based morphometry (VBM) studies of gray matter volume (GMV) in 924 RRMS patients and 204 PPMS patients. This study is registered with PROSPERO (number CRD42019121319). Compared with healthy controls, RRMS and PPMS patients showed gray matter atrophy in the cortico-striatal-thalamic network, sensorimotor network, and bilateral insula. RRMS patients had a larger GMV in the left insula, cerebellum, right precentral gyrus, and bilateral putamen as well as a smaller GMV in the bilateral cingulate, caudate nucleus, right thalamus, superior temporal gyrus and left postcentral gyrus than PPMS patients. The disease duration, Expanded Disability Status Scale score, Paced Auditory Serial Addition Test z-score, and T2-weighted lesion load were associated with specific gray matter regions in RRMS or PPMS. Alterations in the cortico-striatal-thalamic networks, sensorimotor network, and insula may be involved in the common pathogenesis of RRMS and PPMS. The deficits in the cingulate gyrus and caudate nucleus are more apparent in RRMS than in PPMS. The more severe cerebellum atrophy in PPMS may be a brain feature associated with its neurological manifestations. These imaging biomarkers provide morphological evidence for the pathophysiology of MS and should be verified in future research.
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