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Xingxuan He et al.
NEUROBIOLOGY OF AGING (2010)
An Overview of APP Processing Enzymes and Products
Vivian W. Chow et al.
NEUROMOLECULAR MEDICINE (2010)
Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin
Fenghua Hu et al.
NEURON (2010)
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
Marta M. Lipinski et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling
Ying Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Lipid Rafts As a Membrane-Organizing Principle
Daniel Lingwood et al.
SCIENCE (2010)
Novel mutation and the first prenatal screening of cathepsin D deficiency (CLN10)
Karen Fritchie et al.
ACTA NEUROPATHOLOGICA (2009)
Prosaposin Deficiency and Saposin B Deficiency (Activator-Deficient Metachromatic Leukodystrophy): Report on Two Patients Detected by Analysis of Urinary Sphingolipids and Carrying Novel PSAP Gene Mutations
Ladislav Kuchar et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2009)
Progranulin is expressed within motor neurons and promotes neuronal cell survival
Cara L. Ryan et al.
BMC NEUROSCIENCE (2009)
A new subtype of frontotemporal lobar degeneration with FUS pathology
Manuela Neumann et al.
BRAIN (2009)
Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease
Juliane Neumann et al.
BRAIN (2009)
R632W mutation in PLA2G6 segregates with dystonia-parkinsonism in a consanguineous Iranian family
F. Sina et al.
EUROPEAN JOURNAL OF NEUROLOGY (2009)
ApoE4-dependent Aβ-mediated neurodegeneration is associated with inflammatory activation in the hippocampus but not the septum
Haim Belinson et al.
JOURNAL OF NEURAL TRANSMISSION (2009)
Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture
Hirohisa Minagawa et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2009)
Neuropathology of nondemented aging: Presumptive evidence for preclinical Alzheimer disease
Joseph L. Price et al.
NEUROBIOLOGY OF AGING (2009)
ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain
Veera Venkata Ratnam Bandaru et al.
NEUROBIOLOGY OF AGING (2009)
APOE genotype-specific differences in the innate immune response
Michael P. Vitek et al.
NEUROBIOLOGY OF AGING (2009)
APOE ε2 is associated with intact cognition but increased Alzheimer pathology in the oldest old
Daniel J. Berlau et al.
NEUROLOGY (2009)
Longitudinal Modeling of Age-Related Memory Decline and the APOE ε4 Effect
Richard J. Caselli et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
E. Sidransky et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Applicability of current staging/categorization of α-synuclein pathology and their clinical relevance
Laura Parkkinen et al.
ACTA NEUROPATHOLOGICA (2008)
Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): Does APP function as a cholesterol sensor?
Andrew J. Beel et al.
BIOCHEMISTRY (2008)
APOE ε4 lowers age at onset and is a high risk factor for Alzheimer's disease;: A case control study from central Norway
Sigrid B. Sando et al.
BMC NEUROLOGY (2008)
Increased Inflammatory Gene Expression in ABC Transporter-Deficient Macrophages Free Cholesterol Accumulation, Increased Signaling via Toll-Like Receptors, and Neutrophil Infiltration of Atherosclerotic Lesions
Laurent Yvan-Charvet et al.
CIRCULATION (2008)
Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia
Rosa Rademakers et al.
HUMAN MOLECULAR GENETICS (2008)
Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
Philip Van Damme et al.
JOURNAL OF CELL BIOLOGY (2008)
Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease
Suzanne E. Wahrle et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels
David R. Riddell et al.
JOURNAL OF NEUROSCIENCE (2008)
TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
Edor Kabashi et al.
NATURE GENETICS (2008)
NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes
Rodney E. Infante et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
Jemeen Sreedharan et al.
SCIENCE (2008)
Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice
Laurent Yvan-Charvet et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of β-Glucocerebrosidase
David Reczek et al.
CELL (2007)
Neuronal and glial accumulation of α- and β-synucleins in human lipidoses
Kyoko Suzuki et al.
ACTA NEUROPATHOLOGICA (2007)
Mutations in the glucocerebrosidase gene are associated with early-onset Parkinson disease
L. N. Clark et al.
NEUROLOGY (2007)
Clinical diagnostic criteria for dementia associated with Parkinson's disease
Murat Emre et al.
MOVEMENT DISORDERS (2007)
The cholesteryl ester transfer protein (CETP) gene and the risk of Alzheimer's disease
Alejandro Arias-Vasquez et al.
NEUROGENETICS (2007)
Progranulin in frontotemporal lobar degeneration and neuroinflammation
Zeshan Ahmed et al.
JOURNAL OF NEUROINFLAMMATION (2007)
Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17
Matt Baker et al.
NATURE (2006)
Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21
Marc Cruts et al.
NATURE (2006)
Gaucher disease: multiple lessons from a single gene disorder
Ernest Beutler
ACTA PAEDIATRICA (2006)
Cholesteryl ester transfer protein (CETP) polymorphism modifies the Alzheimer's disease risk associated with APOE ε4 allele
E Rodríguez et al.
JOURNAL OF NEUROLOGY (2006)
Deletion of Abca1 increases Aβ deposition in the PDAPP transgenic mouse model of Alzheimer disease
SE Wahrle et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Apolipoprotein (apo) E4 enhances amyloid β peptide production in cultured neuronal cells:: ApoE structure as a potential therapeutic target
SM Ye et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Apolipoprotein E4 enhances brain inflammation by modulation of the NF-κB signaling cascade
G Ophir et al.
NEUROBIOLOGY OF DISEASE (2005)
A PEST deletion mutant of ABCA1 shows impaired internalization and defective cholesterol efflux from late endosomes
WG Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7
M Hayashi et al.
JOURNAL OF LIPID RESEARCH (2005)
Multiple mechanisms mediate cholesterol-induced synaptogenesis in a CNS neuron
C Goritz et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2005)
Extensive involvement of autophagy in Alzheimer disease: An immuno-electron microscopy study
RA Nixon et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2005)
Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport
DE Sleat et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein
S Abe-Dohmae et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain
V Hirsch-Reinshagen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE
SE Wahrle et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response
JR Lynch et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Important link between dementia subtype and apolipoprotein E: a meta-analysis
OY Bang et al.
YONSEI MEDICAL JOURNAL (2003)
Gaucher disease with parkinsonian manifestations: does glucocerebrosidase deficiency contribute to a vulnerability to parkinsonism?
N Tayebi et al.
MOLECULAR GENETICS AND METABOLISM (2003)
Central nervous system inflammation is a hallmark of pathogenesis in mouse models of GM1 and GM2 gangliosidosis
M Jeyakumar et al.
BRAIN (2003)
Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells
A Gómez-Ramos et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2003)
Novel role for apolipoprotein E in the central nervous system - Modulation of sulfatide content
XL Han et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Progranulin is a mediator of the wound response
ZH He et al.
NATURE MEDICINE (2003)
Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts
R Ehehalt et al.
JOURNAL OF CELL BIOLOGY (2003)
Apolipoprotein E4 forms a molten globule -: A potential basis for its association with disease
JA Morrow et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Niemann-Pick type C disease:: Accelerated neurofibrillary tangle formation and amyloid β deposition associated with apolipoprotein E ε4 homozygosity
Y Saito et al.
ANNALS OF NEUROLOGY (2002)
CNS synaptogenesis promoted by glia-derived cholesterol
DH Mauch et al.
SCIENCE (2001)
Acyl-coenzyme A:cholesterol acyltransferase modulates the generation of the amyloid β-peptide
L Puglielli et al.
NATURE CELL BIOLOGY (2001)
A novel mutation in the coding region of the prosaposin gene leads to a complete deficiency of prosaposin and saposins, and is associated with a complex sphingolipidosis dominated by lactosylceramide accumulation
H Hulková et al.
HUMAN MOLECULAR GENETICS (2001)
Endocytic pathway abnormalities precede amyloid β deposition in sporadic Alzheimer's disease and Down syndrome -: Differential effects of APOE genotype and presenilin mutations
AM Cataldo et al.
AMERICAN JOURNAL OF PATHOLOGY (2000)
Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture
M Michikawa et al.
JOURNAL OF NEUROCHEMISTRY (2000)
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