期刊
NEUROCHEMISTRY INTERNATIONAL
卷 145, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2021.105011
关键词
Natural products; Alzheimer?s disease; Huntington?s disease; Parkinson?s disease; Prion disease; Proteinopathies; Proteostasis
资金
- Korea Research Fellowship Program [2018H1D3A1A01074712]
- National Research Foundation of Korea (NRF) - Korean Ministry of Science, ICT, and Future Planning [2018R1A2B6002232]
- National Research Foundation of Korea [2018R1A2B6002232] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This article discusses the relationship between proteostasis and proteinopathies, as well as the effectiveness of using phytochemicals to modulate proteostasis. Modulating proteostasis targeting proteinopathies may be an effective way to prevent the progression of neurodegenerative diseases.
Defective proteostasis is associated with the gradual accumulations of misfolded proteins and is a hallmark of many age-associated neurodegenerative diseases. In the aged brain, maintenance of the proteostasis network presents a substantial challenge, and its loss contributes to the onset and progression of neurological diseases associated with cognitive decline due to the generation of toxic protein aggregates, a process termed ?proteinopathy?. Emerging evidence suggests that reversing proteinopathies by boosting proteostasis might provide an effective means of preventing neurodegeneration. From this perspective, phytochemicals may play significant roles as potent modulators of the proteostasis network, as previous reports have suggested they can interact with various network components to modify pathologies and confer neuroprotection. This review focuses on some potent phytochemicals that directly or indirectly modulate the proteostasis network and on their possible molecular targets. In addition, we propose strategies for the natural product-based modulation of proteostasis machinery that target proteinopathies.
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