GLT8D1 may not be significant in Chinese sporadic amyotrophic lateral sclerosis patients

To detect the mutation frequency of exon 4 of amyotrophic lateral sclerosis (ALS) in a new diseasecausing gene, GLT8D1 (NM_018446), in Chinese patients, we used whole-exome sequencing technology to screen the full-length GLT8D1 gene in 539 Chinese sporadic ALS patients and 176 controls without a history of neurological diseases. Then, we sequenced the coding region of exon 4 in the GLT8D1 gene in a cohort consisting of 256 sporadic ALS patients. Our current results did not find an association between GLT8D1 and ALS in Chinese patients, and further studies will be required. (C) 2021 Elsevier Inc. All rights reserved.

Automated summary

Using whole-exome sequencing, we investigated the mutation frequency of exon 4 of amyotrophic lateral sclerosis (ALS) in the new disease-causing gene GLT8D1 in Chinese patients, but found no association between GLT8D1 and ALS. Further studies are needed to confirm these findings.