期刊
NEURO-ONCOLOGY
卷 23, 期 10, 页码 1777-1788出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/neuonc/noab047
关键词
hypothalamic glioma; MEK-1/2; optic pathway glioma; pediatric low-grade glioma; selumetinib
资金
- NIH/NCI Cancer Center Support Grant [P30 CA008748, UM1CA081457]
- National Cancer Institute Cancer Therapy Evaluation Program
- American Lebanese Syrian Associated Charities
This study presented the results of treating children with recurrent/progressive OPHGs using selumetinib in a PBTC phase II trial. The treatment resulted in partial responses in 24% of patients, stable disease in 56%, and disease progression in 20%, with a median number of 26 treatment courses. The two-year PFS was 78%, and evaluation of visual acuity showed improvement and stability in a portion of patients.
Background. Pediatric low-grade gliomas (pLGGs) are the most common childhood brain tumor. Progression- free survival (PFS) is much lower than overall survival, emphasizing the need for alternative treatments. Sporadic (without neurofibromatosis type 1) optic pathway and hypothalamic gliomas (OPHGs) are often multiply recurrent and cause significant visual deficits. Recently, there has been a prioritization of functional outcomes. Methods. We present results from children with recurrent/progressive OPHGs treated on a PBTC (Pediatric Brain Tumor Consortium) phase II trial evaluating efficacy of selumetinib (AZD6244, ARRY-142886) a MEK-1/2 inhibitor. Stratum 4 of PBTC-029 included patients with sporadic recurrent/progressive OPHGs treated with selumetinib at the recommended phase II dose (25mg/m 2 /dose BID) for a maximum of 26 courses. Results. Twenty-five eligible and evaluable patients were enrolled with a median of 4 (1-11) previous therapies. Six of 25 (24%) had partial response, 14/25 (56%) had stable disease, and 5 (20%) had progressive disease while on treatment.The median treatment courses were 26 (2-26); 14/25 patients completed all 26 courses. Two-year PFS was 78 +/- 8.5%. Nineteen of 25 patients were evaluable for visual acuity which improved in 4/19 patients (21%), was stable in 13/19 (68%), and worsened in 2/19 (11%). Five of 19 patients (26%) had improved visual fields and 14/19 (74%) were stable. The most common toxicities were grade 1/2 CPK elevation, anemia, diarrhea, headache, nausea/emesis, fatigue, AST and ALT increase, hypoalbuminemia, and rash. Conclusions. Selumetinib was tolerable and led to responses and prolonged disease stability in children with recurrent/progressive OPHGs based upon radiographic response, PFS, and visual outcomes.
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