期刊
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
卷 394, 期 7, 页码 1341-1353出版社
SPRINGER
DOI: 10.1007/s00210-021-02072-8
关键词
Mitochondrial dysfunction; Herat injury; Oxidative stress; Inflammation; Apoptosis
资金
- Mashhad University of Medical Sciences
Curcumin has been shown to alleviate chemical and drug-induced cardiac injury by regulating Nrf2 and suppressing p38 MAPK/NF-kappa B and NLRP3 inflammasomes. It also has anti-apoptotic properties that modulate AMPK, Akt, JNK, and ERK signaling pathways in heart tissue. This review explores the potential protective effects of curcumin against detrimental effects in cardiac tissue caused by exposure to various chemicals and drugs.
Cardiotoxicity is a major adverse effect that can be induced by both therapeutic agents and industrial chemicals. The pathogenesis of such cardiac damage is multifactorial, often injuring the cardiac tissue by generating free radicals, oxidative stress, and/or inflammation. Curcumin (CUR) is a bright yellow chemical produced by Curcuma longa plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. Administration of CUR has been reported to ameliorate the chemical and drug-induced cardiac injury in several studies. CUR has been suggested to act as an effective candidate against oxidative stress and inflammation in heart tissue via regulation of Nrf2 and suppression of p38 MAPK/NF-kappa B and NLRP3 inflammasomes. The anti-apoptotic properties of CUR have also been reported to modulate the AMPK, Akt, JNK, and ERK signaling pathways. This review explores the potential protective effects of CUR regarding the detrimental effects often observed in cardiac tissue following exposure to several chemicals including drugs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据