Pathway-based stratification of glioblastoma

A recent report in Nature Cancer proposes that glioblastoma can be stratified into four functional subgroups on the basis of pathway inference from single-cell or bulk gene expression data. The analysis disclosed a pathway-based subgroup of glioblastoma that depends on oxidative phosphorylation and could potentially be targeted with mitochondrial metabolism inhibitors.

Automated summary

The recent report in Nature Cancer suggests that glioblastoma can be classified into four functional subgroups based on pathway inference from gene expression data, with a subgroup reliant on oxidative phosphorylation potentially targeted by mitochondrial metabolism inhibitors.