期刊
NATURE NEUROSCIENCE
卷 24, 期 4, 页码 529-541出版社
NATURE PORTFOLIO
DOI: 10.1038/s41593-021-00800-0
关键词
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资金
- Centre National de la Recherche Scientifique contract [UPR3212]
- Universite de Strasbourg [UPR3212]
- IASP Early Career Research grant 2012
- FP7 Career Integration grant [334455]
- Initiative of Excellence (IDEX) Attractiveness grant 2013
- IDEX Interdisciplinary grant 2015
- University of Strasbourg Institute for Advanced Study (USIAS)
- Foundation Fyssen
- NARSAD [24821]
- ANR JCJC [19-CE16-0011-0]
- ANR-DFG [GR 3619/701]
- Alexander von Humboldt fellowship
- DFG [SFB 1158, GR 3619/13-1, GR 3619/15-1, GR 3619/16-1, AL 2466/1-1]
- Fyssen Foundation
- SNSF-DFG [GR 3619/8-1]
- Fritz Thyssen Foundation
- Alexander von Humboldt Foundation
- PROCOP grant
- Fund for Scientific Research Flanders [12V7519N]
- Russian Science Foundation RSF [17-75-10061]
- NIMH [ZIAMH002498]
- National Institutes of Health [R01NS094640, R01HL090948]
- European Research Council [683154]
- European Union's Horizon 2020 Research and Innovation Program (Marie Sklodowska-Curie Innovative Training Networks) [722053]
- [0671-2020-0059]
- [SFB1158]
- [SFB/TRR 152]
- [ERC-CoG-772395]
- Russian Science Foundation [17-75-10061] Funding Source: Russian Science Foundation
This study reveals a morphologically distinct subpopulation of astrocytes expressing OT receptors in the central amygdala of mice and rats, mediating the anxiolytic and positive reinforcement effects of OT. It challenges the traditional belief that OT exclusively acts on neurons, highlighting the essential role of astrocytes in modulating emotional states under normal and chronic pain conditions.
Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby, suppresses fear responses and decreases anxiety levels. Using astrocyte-specific gain and loss of function and pharmacological approaches, we demonstrate that a morphologically distinct subpopulation of astrocytes expresses OT receptors and mediates anxiolytic and positive reinforcement effects of OT in the central amygdala of mice and rats. The involvement of astrocytes in OT signaling challenges the long-held dogma that OT acts exclusively on neurons and highlights astrocytes as essential components for modulation of emotional states under normal and chronic pain conditions.
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