Antitumor γδ T cells need oxygen to function

Brain tumors respire more oxygen, causing a hypoxic microenvironment that impairs innate gamma delta T cell-mediated antitumor activity. Reducing oxygen consumption by brain tumors or inhibiting hypoxia-inducible factor-1 alpha in gamma delta T cells reinvigorates gamma delta T cell tumor-killing activity, leading to prolonged survival in brain-tumor-bearing mice.

Automated summary

Brain tumors consume more oxygen, resulting in a hypoxic microenvironment that impairs innate gamma delta T cell-mediated antitumor activity. However, by reducing oxygen consumption in brain tumors or inhibiting hypoxia-inducible factor-1 alpha in gamma delta T cells, the tumor-killing activity of gamma delta T cells can be rejuvenated, leading to prolonged survival in mice with brain tumors.