期刊
NATURE
卷 591, 期 7851, 页码 659-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41586-021-03309-5
关键词
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资金
- NIH [R35 GM126950, RM1 GM136511, F31 GM123644, R37 AI036929]
- CHOP MitoRAG Pilot Grant
- HHMI investigator support
- HHMI Gilliam Fellowship
- NIAMS/NIH [K08 AR075846, P30 AR069589]
- Dermatology Foundation
- National Psoriasis Foundation
- UPenn NGG Hearst Fellowship
- German Research Foundation (DFG) [BO 5434/1-1]
- HHMI
- [F30NS092227]
Actin assemblies play important roles in mitochondrial organization and inheritance during mitosis, ensuring equal segregation of mitochondrial mass at cytokinesis. Actin filaments on the surface of mitochondria form comet tails, promoting randomly directed bursts of movement to randomize inheritance of healthy and damaged mitochondria between daughter cells in symmetric cell division.
Symmetric cell division requires the even partitioning of genetic information and cytoplasmic contents between daughter cells. Whereas the mechanisms coordinating the segregation of the genome are well known, the processes that ensure organelle segregation between daughter cells remain less well understood(1). Here we identify multiple actin assemblies with distinct but complementary roles in mitochondrial organization and inheritance in mitosis. First, we find a dense meshwork of subcortical actin cables assembled throughout the mitotic cytoplasm. This network scaffolds the endoplasmic reticulum and organizes three-dimensional mitochondrial positioning to ensure the equal segregation of mitochondrial mass at cytokinesis. Second, we identify a dynamic wave of actin filaments reversibly assembling on the surface of mitochondria during mitosis. Mitochondria sampled by this wave are enveloped within actin clouds that can spontaneously break symmetry to form elongated comet tails. Mitochondrial comet tails promote randomly directed bursts of movement that shuffle mitochondrial position within the mother cell to randomize inheritance of healthy and damaged mitochondria between daughter cells. Thus, parallel mechanisms mediated by the actin cytoskeleton ensure both equal and random inheritance of mitochondria in symmetrically dividing cells.
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