期刊
NATURAL PRODUCT RESEARCH
卷 36, 期 6, 页码 1631-1635出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2021.1893316
关键词
Apigenin; gamma radiation; gastrointestinal toxicity; apoptosis
资金
- Indian Council of Medical Research (ICMR) [3/2/2/3/10-NCDIII, 2009-08970]
- New Delhi, India
Pre-treatment with apigenin shows a protective effect against radiation-induced gastrointestinal damages in Swiss albino mice, improving intestinal architecture and modulating apoptotic signaling pathways.
The objective of this study was to evaluate the protective effect of apigenin against radiation-induced gastrointestinal (GI) damages in whole-body irradiated (WBI) Swiss albino mice. Swiss albino mice were pre-treated with apigenin (15 mg/kg body wt.) intraperitoneally for six consecutive days, and on the seventh day, the mice were exposed to 7 Gy WBI. Histological findings revealed a deterioration of the crypt-villus architecture in the 7 Gy irradiated mice intestine. Conversely, apigenin pre-treatment ameliorated radiation-induced intestinal damages and restored intestinal crypt-villus architecture. Besides, apigenin modulates 7 Gy radiation-induced apoptotic markers (p53, p21, Bax, caspase-3, -9) expression in the GI tissue of WBI mice. Furthermore, apigenin prevented radiation-induced activation of NF-kB expression in the GI tissue. Therefore, the present results indicate apigenin's radioprotective effect through modulating NF-kB mediated apoptotic signalling in the WBI intestinal tissue.
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