期刊
NATURAL PRODUCT COMMUNICATIONS
卷 16, 期 2, 页码 -出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1934578X21991687
关键词
Cyperus rotundus L.; terpenoids; sesquiterpenoids; bioactivity; NF-kappa B pathway
资金
- National Natural Science Foundation of China [31760095, 81960639, 21768005]
- Yunnan province key laboratory construction plan funding of universities
- Yunnan province engineering research center construction plan
Two new sesquiterpenoids, along with 6 known sesquiterpenoids, were isolated from the rhizomes of Cyperus rotundus L. All compounds were structurally elucidated and tested for their inhibitory activity on the NF-κB signaling pathway, with 7 compounds showing varying degrees of inhibition.
Two new sesquiterpenoids, isocyperotundone (1) and 1,4-epoxy-4-hydroxy-4,5-seco-guain-11-en-5-one (2), together with 6 known sesquiterpenoids, cyperotundone (3), cyperenoic acid (4), sugetriol triacetate (5), cyperusol A(3) (6), cyperusol A(2) (7), and cyperusol A(1) (8), were isolated from the methanol extract of the rhizomes of Cyperus rotundus L. High-resolution electrospray ionization mass spectrometry and 1-dimensional (1D) and 2D nuclear magnetic resonance spectroscopy were used to establish the structures of all the compounds. All the compounds were tested for activity on nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) signaling. Compounds 1-7 exhibited inhibitory activity on tumor necrosis factor-a-induced activation of the NF-kappa B pathway, with half-maximal inhibitory concentration values ranging from 34.5 to 73.7 mu mol/L.
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