期刊
NANOTECHNOLOGY
卷 32, 期 24, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1361-6528/abed03
关键词
theranostic ultrasound molecular probe; triple-negative breast cancer; doxorubicin; targeted therapy; cardioprotection
资金
- International Science & Technology Cooperation Program of China [2015DFA30920]
- National Natural Science Foundation of China [81771856]
The AS1411-DOX-NBs showed enhanced tumour cell-killing ability in vitro by increasing the active uptake of drugs, and significantly inhibited the growth of TNBC xenografts while maintaining the weight and health of the mice. Echocardiography and pathological examination confirmed that AS1411-DOX-NBs effectively induced tumour tissue apoptosis and necrosis while reducing DOX-induced cardiotoxicity.
Targeted lipid nanobubbles as theranostic ultrasound molecular probes with both targeted contrast-enhanced ultrasound molecular imaging and synergistic treatment capabilities are expected to overcome severe challenges in the diagnosis and treatment of refractory triple-negative breast cancer (TNBC). In this study, AS1411 aptamer-functionalised nucleolin-targeted doxorubicin-loaded lipid nanobubbles (AS1411-DOX-NBs) were constructed, and their physicochemical properties as well as anti-tumour and cardioprotective efficacies were systematically tested and evaluated. The results showed that AS1411-DOX-NBs can carry and maintain the physicochemical and pharmacodynamic properties of doxorubicin (DOX) and show stronger tumour cell-killing ability in vitro by increasing the active uptake of drugs. AS1411-DOX-NBs also significantly inhibited the growth of TNBC xenografts while maintaining the weight and health of the mice. Echocardiography and pathological examination further confirmed that AS1411-DOX-NBs effectively caused tumour tissue apoptosis and necrosis while reducing DOX-induced cardiotoxicity. The AS1411-DOX-NBs constructed in this study enable both targeted contrast-enhanced ultrasound molecular imaging and synergistic therapeutic efficacy and can be used as safe and efficient theranostic ultrasound molecular probes for the diagnosis and treatment of TNBC.
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