期刊
NANOMEDICINE
卷 16, 期 8, 页码 673-680出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2020-0450
关键词
chimeric; HIV-1; mosaic; nanoparticles; nanovaccine; SAPN; vaccines
资金
- Henry M Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-11-2-0174]
- US Department of Defense (DOD) [W81XWH-11-2-0174]
Developing an efficacious HIV-1 vaccine has been challenging due to the virus's diversity. Various approaches, such as sequence optimization and the use of protein nanoparticles, may need to be combined to overcome this obstacle.
An efficacious HIV-1 vaccine has remained an elusive target for almost 40 years. The sheer diversity of the virus is one of the major roadblocks for vaccine development. HIV-1 frequently mutates and various strains predominate in different geographic regions, making the development of a globally applicable vaccine extremely difficult. Multiple approaches have been taken to overcome the issue of viral diversity, including sequence optimization, development of consensus and mosaic sequences and the use of different prime-boost approaches. To develop an efficacious vaccine, these approaches may need to be combined. One way to potentially synergize these approaches is to use a rationally designed protein nanoparticle that allows for the native-like presentation of antigens, such as the self-assembling protein nanoparticle.
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