期刊
NANO LETTERS
卷 21, 期 3, 页码 1335-1344出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.0c04053
关键词
Microfluidics; BioZIF-8 MOFs; drug delivery; tumor; lymph nodes
类别
资金
- National Key R&D Program of China [2018YFA0902600, 2017YFA0205901]
- National Natural Science Foundation of China [21535001, 81730051, 21761142006]
- Chinese Academy of Sciences [QYZDJ-SSW-SLH039, 121D11KYSB20170026, XDA16020902]
- Tencent Foundation through the XPLORER PRIZE
This study developed an integrated microfluidic chip to synthesize aptamer-modified biozeolitic imidazolate framework for targeting lymph nodes and tumors. The approach reduced synthesis time, encapsulated more biomolecules, and realized the rapid and fine-tuned synthesis of functional MOFs in one step.
Targeted delivery of therapeutic molecules using nanomaterials is desired to elicit specific responses toward diseases. Such an integrated synthesis of functional material using a microfluidic approach is a great challenge. Functional metal organic frameworks (MOFs) with unique structural diversity possess a complicated synthesis procedure thereby requiring a modest, straightforward approach to synthesize size-controllable MOFs. Here, we develop an integrated microfluidic chip to synthesize the aptamer-modified biozeolitic imidazolate framework (BioZIF-8) to target the lymph node and tumor. The first stage of the microfluidic chip forms the ZIF-8 encapsulating biomolecules (bovine serum albumin, small interfering ribonucleic acid, and doxorubicin). The second stage modifies the surface of BioZIF-8 with the aptamer. Our approach reduces the overall synthesis time (similar to 3 mg/10 min against 15 h for the conventional two-step method) and encapsulates a higher number of biomolecules. The microfluidic approach realizes the rapid and fine-tuned synthesis of functional MOFs integrated into one-step.
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