Antimicrobial Metabolites against Methicillin-Resistant Staphylococcus aureus from the Endophytic Fungus Neofusicoccum australe

Antimicrobial bioassay-guided fractionation of the endophytic fungi Neofusicoccum australe led to the isolation of a new unsymmetrical naphthoquinone dimer, neofusnaphthoquinone B (1), along with four known natural products (2-5). Structure elucidation was conducted by nuclear magnetic resonance (NMR) spectroscopic methods, and the antimicrobial activity of all the natural products was investigated, revealing 1 to be moderately active towards methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 16 mu g/mL.

Automated summary

Antimicrobial bioassay-guided fractionation of the endophytic fungi Neofusicoccum australe resulted in the isolation of a new unsymmetrical naphthoquinone dimer, neofusnaphthoquinone B (1), along with four known natural products. The antimicrobial activity of all the compounds was investigated, with compound 1 showing moderate activity against methicillin-resistant Staphylococcus aureus (MRSA) at a minimum inhibitory concentration of 16 μg/mL.