期刊
MOLECULES
卷 26, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/molecules26040781
关键词
angiogenesis; endothelial cell; proliferation; tube formation; migration; Ulmus davidiana
资金
- National Research Foundation of Korea - Korean government [NRF-2020R1I1A3071928, NRF-2019R1I1A1A01057005]
- R&D program for Forest Science Technology by Korea Forest Service (Korea Forestry Promotion Institite) [201703B10-1819-BA01]
Angiogenesis plays a crucial role in various diseases, and the Ulmus davidiana extract U60E can alleviate symptoms by inhibiting VEGF-induced angiogenesis.
As abnormal angiogenesis is associated with exacerbation of various diseases, precise control over angiogenesis is imperative. Vascular endothelial growth factor (VEGF), the most well-known angiogenic factor, binds to VEGF receptor (VEGFR), activates various signaling pathways, and mediates angiogenesis. Therefore, blocking the VEGF-induced angiogenic response-related signaling pathways may alleviate various disease symptoms through inhibition of angiogenesis. Ulmus davidiana is a safe natural product that has been traditionally consumed, but its effects on endothelial cells (ECs) and the underlying mechanism of action are unclear. In the present study, we focused on the effect of a 60% edible ethanolic extract of U. davidiana (U60E) on angiogenesis. U60E inhibited the VEGF-mediated proliferation, tube formation, and migration ability of ECs. Mechanistically, U60E inhibited endothelial nitric oxide synthase activation and nitric oxide production by blocking the protein kinase B signaling pathway activated by VEGF and consequently inhibiting proliferation, tube formation, and migration of ECs. These results suggest that U60E could be a potential and safe therapeutic agent capable of suppressing proangiogenic diseases by inhibiting VEGF-induced angiogenesis.
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