期刊
MOLECULES
卷 26, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/molecules26051440
关键词
antifungal efficacy; biocompatibility; Candida albicans; Cnidium officinale; denture-relining material; surface characterization
资金
- National Research Foundation of Korea (NRF) [2020R1C1C1009703]
- National Research Foundation of Korea [2020R1C1C1009703] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The denture-lining material containing Cnidium officinale extract showed comparable biocompatibility to the control group, but exhibited significantly higher antifungal efficacy against Candida albicans. This suggests the potential of using Cnidium officinale extract in dental materials for antifungal purposes.
Herein, we investigated the surface characterization and biocompatibility of a denture-lining material containing Cnidium officinale extracts and its antifungal efficacy against Candida albicans. To achieve this, a denture-lining material containing various concentrations of C. officinale extract and a control group without C. officinale extract were prepared. The surface characterization and biocompatibility of the samples were investigated. In addition, the antifungal efficacy of the samples on C. albicans was investigated using spectrophotometric growth and a LIVE/DEAD assay. The results revealed that there was no significant difference between the biocompatibility of the experimental and control groups (p > 0.05). However, there was a significant difference between the antifungal efficiency of the denture material on C. albicans and that of the control group (p < 0.05), which was confirmed by the LIVE/DEAD assay. These results indicate the promising potential of the C. officinale extract-containing denture-lining material as an antifungal dental material.
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