期刊
MOLECULES
卷 26, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/molecules26051201
关键词
Tagetes erecta L; Asteraceae; HR-QTOF; MS; polyphenols; quercetagitrin; lipoxygenase
资金
- Ministry of Education and Research, Romania, CNCSUEFISCDI [PN-III-P1-1.1-MC-2017-0956]
Tagetes erecta L. is a popular ornamental plant widely cultivated for decorative purposes and lutein extraction. The plant contains various secondary metabolites, such as polyphenols, which may have important biological activities. Phytochemical analysis of methanolic extract from T. erecta inflorescences revealed the presence of polyphenolic compounds, including flavonols and hydroxycinnamic acid derivatives. A fraction containing quercetagitrin showed promising antioxidant and cytotoxic activities in vitro. Further purification and structural analysis of compounds from T. erecta extracts are warranted based on these results.
Tagetes erecta L. is a popular ornamental plant of the Asteraceae family, which is widely cultivated not only for its decorative use, but also for the extraction of lutein. Besides carotenoid representatives, which have been extensively studied, other important classes of secondary metabolites present in the plant, such as polyphenols, could exhibit important biological activities. The phytochemical analysis of a methanolic extract obtained from T. erecta inflorescences was achieved using liquid chromatography-mass spectrometry (LC-MS) techniques. The extract was further subjected to a multistep purification process, which allowed the separation of different fractions. The total extract and its fractions contain several polyphenolic compounds, such as hydroxybenzoic and hydroxycinnamic acid derivatives, flavonols (especially quercetagetin glycosides), and several aglycons (e.g., quercetin, patuletin). One of the fractions, containing mostly quercetagitrin, was subjected to two different antioxidant assays (metal chelating activity and lipoxygenase inhibition) and to in vitro cytotoxicity assessment. Generally, the biological assays showed promising results for the investigated fraction compared to the initial extract. Given the encouraging outcome of the in vitro assays, further purification and structural analysis of compounds from T. erecta extracts, as well as further in vivo investigations are justified.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据