期刊
MOLECULES
卷 26, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/molecules26041016
关键词
oxidative stress; Nrf2; bioactive compounds; food; diseases
资金
- National Key R&D Program of China [2018YFA0106902]
- National Natural Science Foundation of China [81902637]
- Natural Science Foundation of Jilin [20200404078YY]
Oxidative stress is linked to diseases, while Nrf2/ARE pathway plays a crucial role in response to oxidative stress. Regulation of Nrf2/ARE pathway is an effective method for treating oxidative stress-related diseases.
Oxidative stress, which refers to unbalanced accumulation of reactive oxygen species (ROS) levels in cells, has been linked to acute and chronic diseases. Nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) pathway plays a vital role in regulating cytoprotective genes and enzymes in response to oxidative stress. Therefore, pharmacological regulation of Nrf2/ARE pathway is an effective method to treat several diseases that are mainly characterized by oxidative stress and inflammation. Natural products that counteract oxidative stress by modulating Nrf2 have contributed significantly to disease treatment. In this review, we focus on bioactive compounds derived from food that are Nrf2/ARE pathway regulators and describe the molecular mechanisms for regulating Nrf2 to exert favorable effects in experimental models of diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据