The Expanding Regulatory Mechanisms and Cellular Functions of Long Non-coding RNAs (lncRNAs) in Neuroinflammation

LncRNAs have emerged as important regulatory molecules in biological processes. They serve as regulators of gene expression pathways through interactions with proteins, RNA, and DNA. LncRNA expression is altered in several diseases of the central nervous system (CNS), such as neurodegenerative disorders, stroke, trauma, and infection. More recently, it has become clear that lncRNAs contribute to regulating both pro-inflammatory and anti-inflammatory pathways in the CNS. In this review, we discuss the molecular pathways involved in the expression of lncRNAs, their role and mechanism of action during gene regulation, cellular functions, and use of lncRNAs as therapeutic targets during neuroinflammation in CNS disorders.

Automated summary

Long non-coding RNAs (lncRNAs) have emerged as important regulators in biological processes, interacting with proteins, RNA, and DNA to regulate gene expression pathways. Altered lncRNA expression in CNS diseases contributes to regulating both pro-inflammatory and anti-inflammatory pathways. The review discusses molecular pathways, mechanisms, and therapeutic potential of lncRNAs in CNS disorders related to neuroinflammation.