期刊
MOLECULAR MEDICINE REPORTS
卷 23, 期 5, 页码 -出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2021.11986
关键词
cyclooxygenase-2; microRNAs; therapeutic target; cyclooxygenase-2 inhibitors; cancer; inflammation
资金
- Chinese National Science Foundation [81172210]
- China Postdoctoral Science Foundation [2012M521528]
Tumor-associated inflammation and aberrantly expressed biomarkers play crucial roles in the cancer microenvironment. COX-2, as a prominent inflammatory factor, is highly expressed in tumor cells and contributes to tumor growth, recurrence, and metastasis. Understanding the regulatory role of miRNAs in COX-2 post-transcriptional processes could provide new insights for developing novel COX-2 selective inhibitors based on miRNAs.
Tumor-associated inflammation and aberrantly expressed biomarkers have been demonstrated to play crucial roles in the cancer microenvironment. Cyclooxygenase-2 (COX-2), a prominent inflammatory factor, is highly expressed in tumor cells and contributes to tumor growth, recurrence and metastasis. Overexpression of COX-2 may occur at both transcriptional and post-transcriptional levels. Thus, an improved understanding of the regulatory mechanisms of COX-2 can facilitate the development of novel antitumor therapies. MicroRNAs (miRNAs) are a group of small non-coding RNAs that act as translation repressors of target mRNAs, and play vital roles in regulating cancer development and progression. The present review discusses the association between miRNAs and COX-2 expression in different types of cancer. Understanding the regulatory role of miRNAs in COX-2 post-transcription can provide novel insight for suppressing COX-2 expression via gene silencing mechanisms, which offer new perspectives and future directions for the development of novel COX-2 selective inhibitors based on miRNAs.
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