A time to build and a time to burn: glucose metabolism for every season

Luengo et al. (2020) demonstrate that pyruvate dehydrogenase (PDH) overactivation blunts NAD(+) regeneration by overcharging the mitochondrial membrane potential and driving ATP synthesis beyond demand. Under these conditions, some cells prioritize aerobic glycolysis to meet the need for oxidized cofactors in biosynthetic metabolism.

Automated summary

Luengo et al. (2020) demonstrate that overactivation of pyruvate dehydrogenase (PDH) impairs NAD(+) regeneration by altering mitochondrial membrane potential and driving ATP synthesis beyond demand, leading some cells to prioritize aerobic glycolysis to meet the requirement for oxidized cofactors in biosynthetic metabolism.