期刊
MOLECULAR BIOLOGY AND EVOLUTION
卷 38, 期 7, 页码 2804-2817出版社
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msab070
关键词
demography; admixture; adaptation; exomes; Roma; mutational load
资金
- Spanish Ministry of Science, Innovation and Universities (MCIU)
- Agencia Estatal de Investigacion (AEI) [CGL2016-75389-P, PID2019-106485GB-I00/AEI/10.13039/501100011033]
- Unidad de Excelencia Maria de Maeztu(AEI) [CEX2018-000792-M]
- [FPU17/03501]
The study reveals that the Roma genomes exhibit a long-term balance under the effects of founder effects and gene flow, providing insights into the genetic variation in admixed populations.
Demographic history plays a major role in shaping the distribution of genomic variation. Yet the interaction between different demographic forces and their effects in the genomes is not fully resolved in human populations. Here, we focus on the Roma population, the largest transnational ethnic minority in Europe. They have a South Asian origin and their demographic history is characterized by recent dispersals, multiple founder events, and extensive gene flow from non-Roma groups. Through the analyses of new high-coverage whole exome sequences and genome-wide array data for 89 Iberian Roma individuals together with forward simulations, we show that founder effects have reduced their genetic diversity and proportion of rare variants, gene flow has counteracted the increase in mutational load, runs of homo-zygosity show ancestry-specific patterns of accumulation of deleterious homozygotes, and selection signals primarily derive from preadmixture adaptation in the Roma population sources. The present study shows how two demographic forces, bottlenecks and admixture, act in opposite directions and have long-term balancing effects on the Roma genomes. Understanding how demography and gene flow shape the genome of an admixed population provides an opportunity to elucidate how genomic variation is modeled in human populations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据