期刊
MOLECULAR AND CELLULAR NEUROSCIENCE
卷 111, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mcn.2021.103590
关键词
Nerve injury; Nerve regeneration; Macrophage; Neuromuscular junction; Glial cells
资金
- NIH National Institute of Neurological Disorders and Stroke [K08NS096232]
- NIH National Heart Lung Blood Institute training grant [5 T35 HL 7815-25]
Macrophages play crucial roles in repairing peripheral nerve injuries and promoting NMJ reinnervation, suggesting their potential in facilitating motor recovery.
Peripheral nerve injuries remain challenging to treat despite extensive research on reparative processes at the injury site. Recent studies have emphasized the importance of immune cells, particularly macrophages, in recovery from nerve injury. Macrophage plasticity enables numerous functions at the injury site. At early time points, macrophages perform inflammatory functions, but at later time points, they adopt pro-regenerative phenotypes to support nerve regeneration. Research has largely been limited, however, to the injury site. The neuromuscular junction (NMJ), the synapse between the nerve terminal and end target muscle, has received comparatively less attention, despite the importance of NMJ reinnervation for motor recovery. Macrophages are present at the NMJ following nerve injury. Moreover, in denervating diseases, such as amyotrophic lateral sclerosis (ALS), macrophages may also play beneficial roles at the NMJ. Evidence of positive macrophages roles at the injury site after peripheral nerve injury and at the NMJ in denervating pathologies suggest that macrophages may promote NMJ reinnervation. In this review, we discuss the intersection of nerve injury and immunity, with a focus on macrophages.
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