期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 21, 期 14, 页码 1813-1829出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557521666210212150504
关键词
Limonene; perillyl alcohol; anticancer; conjugation; hybrid; thiosemicarbazone; carbohydrate
资金
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Brazil (CAPES) [001]
- CAPES
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) [FAPERGS/PPSUS/CNPq 17/255100013980, FAPERGS/PPSUS/CNPq 17/2551-0001-398-0]
This review summarizes the synthetic methods and strategies for obtaining anticancer derivatives of limonene and perillyl alcohol from 2000 to 2020, discusses the structure-activity relationships of the most active derivatives, and illustrates potential anticancer compounds.
Limonene and perillyl alcohol are natural monoterpenes that have attracted the attention of medicinal chemists due to their promising anticancer activities. Considering this, both compounds were explored as scaffolds to obtain various derivatives with anticancer activity. In this review, the data are organized for the first time, with a focus on the synthetic methods and strategies to obtain the derivatives throughout the period from 2000 to 2020. A brief discussion regarding the structure and activity relationships of the most active derivatives, stereoisomers, and their mechanisms of action is presented. Among the active compounds, a series of limonenes with thiosemicarbazone groups and perillyl alcohol hybrids with glycosides or drugs are illustrated. Taking all of this into account, this review may help researchers develop new promising anticancer candidates based on the structures of limonene and perillyl alcohol.
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