4.5 Article

Antifungal effects of Streptococcus mutans extract on Candida strains susceptible and resistant to fluconazole: An in vivo study

期刊

MEDICAL MYCOLOGY
卷 59, 期 7, 页码 744-747

出版社

OXFORD UNIV PRESS
DOI: 10.1093/mmy/myab008

关键词

Streptococcus mutans; Candida albicans; Candida glabrata; Candida krusei; Galleria mellonella

资金

  1. National Council for Scientific and Technological Development (CNPq): Researcher on Productivity PQ-1C [306330/2018-0]
  2. Sao Paulo Research Foundation (FAPESP) [2016/03395-4, 2016/05226-5]
  3. Coordination for the Improvement of Higher Education Personnel (CAPES)

向作者/读者索取更多资源

The study found that the crude extract of Streptococcus mutans has antifungal effects on clinical Candida strains susceptible and resistant to fluconazole in the Galleria mellonella model, while not affecting certain strains.
Previous studies showed that the crude extract obtained from Streptococcus mutans inhibited the growth of Candida albicans reference strains. In this study, we evaluated whether the antifungal effects of S. mutans extract can be extended to clinical Candida isolates, including C. albicans and non-abicans strains with different susceptibilities to fluconazole. We verified that S. mutans extract increased the survival of Galleria mellonella larvae infected with C. albicans and C. glabrata and inhibited the fungal cells in hemolymph. These antifungal effects occurred for both fluconazole-susceptible and fluconazole-resistant strains. However, larvae infected by C. krusei were not affected by S. mutans extract. Lay Summary Streptococcus mutans crude extract shows antifungal effects on clinical Candida strains susceptible and resistant to fluconazole in Galleria mellonella model.

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