期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2021.111922
关键词
Bacterial cellulose; Air-dried conduit; Small-caliber vascular prosthesis; Characterization; In vivo evaluation; Rabbit model
资金
- Fundamental Research Funds for the Central Universities [2232019A3-08]
- National Key Research and Development Program of China [2018YFC1105501]
- National Natural Science Foundation of China [51373031]
- Innova-tion Foundation of Donghua University [CUSF-DH-D-2018073]
There are currently no commercially available small-caliber vascular prostheses (<6mm) worldwide. Bacterial nanocellulose (BNC) shows promise as a material for small-caliber artificial blood vessels. BNC-Dry conduits demonstrated superior mechanical properties, hemocompatibility, and cytocompatibility compared to BNC-Gel conduits in this study, remaining patent and covered with autologous tissue after placement in rabbit carotid arteries for 46 days. This suggests that BNC-Dry conduits could be a convenient and effective option for surgical applications as small-diameter blood vessels.
There are no small-caliber (<6 mm) vascular prostheses so far commercially available around the globe. Bacterial nanocellulose (BNC) is considered a promising material for small-caliber artificial blood vessel applications. Although BNC hydrogel-like (BNC-Gel) materials possess a 3D network structure, facilitating nutrient exchange when used as vascular prostheses, they are difficult to suture during surgery due to their softness. Furthermore, a water content greater than 99% prevents the material from convenient methods of preservation and transport. Air-drying the BNC (BNC-Dry) would solve these problems. The comparative morphology, mechanical properties, hemocompatibility, and cytocompatibility of the BNC-Gel and BNC-Dry conduits of 3 mm in diameter were recorded in the present study, the results indicating that the mechanical properties, hemocompatibility, and cytocompatibility of BNC-Dry conduits were superior to conduits of BNC-Gel. Forty-six days after replacement of the carotid artery in New Zealand white rabbits, the BNC-Dry conduits remained patent. Composite blood vessels composed of cellulose and autologous tissue were harvested for immunohistochemistry and immunofluorescence staining. Sections demonstrated that the outer walls of the conduits were wrapped with autologous tissue. Contractile smooth muscle cells (SMCs) were observed on the outer surface of the conduit, similar to that observed in natural blood vessels. BNC-Dry conduits exhibited excellent performance and possessed properties convenient for surgical applications as small-diameter blood vessels.
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