Blood clots and tissue regeneration of 3D printed dual scale porous polymeric scaffolds

Blood clotting on implanted porous scaffolds has been suggested to be key to tissue regeneration. We recently reported a new type of 3D printed macroscale porous scaffolds with intra-strut microscale pores, that supported strong bone regeneration in vivo. Yet it remains unclear the effects of this microscale porosity on blood clots. Here, we studied the morphology of the blood clots at the interface with the scaffolds in vitro and analysed the scaffold-tissue interface in vivo. We then suggested a novel role of the scaffold's microscale pores and surface roughness in supporting bone formation via their effects on blood infiltration and clotting. (c) 2020 Elsevier B.V. All rights reserved.

Automated summary

Researchers studied the morphology of blood clots on implanted porous scaffolds and suggested a novel role of the scaffold's microscale pores and surface roughness in supporting bone formation.