Camptothecin-loaded holmium ferrite nanocarrier. Expanded activity on breast cancer cells

To achieve magnetic field-assisted drug delivery, magnetic nanocarriers have to be designed. In this paper, we report the synthesis of holmium ferrite nanoparticles. The nanoparticles are coated with cyclodextrin-polyethylene glycol conjugate. The nanoparticles are characterized using X-ray diffraction, EDX, and XPS. The nanoparticles are of the size range suitable for effective drug delivery. The holmium ferrite nanoparticles are superparamagnetic. An anticancer drug, camptothecin, is loaded on the nanocarrier with an adsorption percentage of 92%. The efficacy of the anticancer drug is enhanced on employing the magnetic nanocarrier. (c) 2020 Elsevier B.V. All rights reserved.

Automated summary

This paper reports the synthesis of holmium ferrite nanoparticles and their application in drug delivery, demonstrating their suitable size and superparamagnetic properties, successful loading of the anticancer drug camptothecin, and potential enhancement of drug efficacy.